Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

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Are you craving a spicy, creamy comfort dish that pulls you in with its aroma and doesn’t let go until the last bite? This Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce is bold, buttery, and absolutely unforgettable.

Imagine forkfuls of spaghetti coated in a luscious, cheesy garlic sauce, paired with crispy Cajun-seasoned chicken and that irresistible mozzarella pull. Whether it’s for a cozy dinner at home or to impress friends over the weekend, this recipe brings restaurant-level indulgence to your table without the fuss.

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Preparation Phase & Tools to Use

To make this dish efficiently, it helps to have the right tools ready:

• Cast Iron Skillet or Grill Pan: This is essential for getting a great sear on your Cajun chicken. It retains high heat and gives that gorgeous char.
• Large Pot: You’ll need this to boil your spaghetti evenly without clumping.
• Saucepan: Use this for making the garlic mozzarella sauce. A heavy-bottomed saucepan is ideal to prevent scorching the dairy.
• Tongs & Whisk: Tongs help turn the chicken without piercing it and drying it out, while a whisk ensures a smooth, emulsified sauce.
• Microplane or Garlic Press: For getting the garlic finely grated into the sauce.

Having these on hand not only speeds up prep but elevates the quality of each element in the dish.

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Ingredients for the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

• Boneless Skinless Chicken Breasts: The star protein. Cajun seasoning soaks beautifully into the meat for deep flavor.
• Cajun Seasoning: This spice blend adds heat and depth; it’s what gives the dish its bold personality.
• Spaghetti: Classic and neutral, it acts as a perfect vehicle for the creamy, garlicky sauce.
• Garlic (Fresh): Adds fragrant, pungent flavor to the mozzarella sauce.
• Heavy Cream: For that rich, velvety texture that hugs the noodles.
• Mozzarella Cheese (Shredded): Melts into the cream, giving that signature cheesy stretch.
• Parmesan Cheese (Optional): For a salty, nutty finish that balances the creamy sauce.
• Olive Oil: For searing the chicken and helping seasoning stick.
• Butter: Enriches the sauce and blends flavors beautifully.
• Chopped Parsley (Optional): Adds a bright, fresh contrast to the richness.

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How To Make the Creamy Cajun Chicken Spaghetti with Garlic Mozzarella Sauce

Step 1: Season and Sear the Chicken

Pat the chicken breasts dry, rub generously with Cajun seasoning, and heat olive oil in a cast iron skillet. Sear the chicken over medium-high heat for about 5–7 minutes per side until blackened and cooked through. Let rest, then slice.

Step 2: Boil the Pasta

While the chicken is cooking, bring a large pot of salted water to a boil. Cook spaghetti until al dente, then drain and set aside.

Step 3: Make the Garlic Mozzarella Sauce

In a saucepan, melt butter and add the minced garlic. Let it simmer for 30 seconds to release its aroma. Add the heavy cream and bring to a low simmer. Slowly whisk in mozzarella (and Parmesan if using) until smooth and stretchy.

Step 4: Combine Pasta and Sauce

Toss the cooked spaghetti into the sauce and stir until every strand is coated. Add chopped parsley if desired.

Step 5: Serve and Assemble

Twirl pasta onto a plate and top with sliced Cajun chicken. Spoon over extra sauce, garnish with parsley, and serve hot.

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Best Ways to Serve and Store This Flavorful Dish

Serve this dish fresh and hot for the ultimate creamy texture and stretch. Pair it with garlic bread or a fresh green salad to balance the richness. For storing, place leftovers in an airtight container in the refrigerator for up to 3 days. Reheat on the stove with a splash of milk or cream to revive the sauce’s silkiness.

Avoid freezing, as the cheese sauce may separate upon thawing.

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Frequently Asked Questions

Can I use a different type of pasta?

Absolutely. Fettuccine, linguine, or penne work well too. Just choose something that holds sauce nicely.

What if I don’t have Cajun seasoning?

You can make your own with paprika, cayenne, garlic powder, onion powder, oregano, thyme, and a touch of salt and pepper.

Can I add vegetables to this dish?

Yes! Sauteed bell peppers, spinach, or mushrooms pair wonderfully and add color and nutrition.

Is there a dairy-free version?

Try using full-fat coconut milk and a vegan cheese alternative. The flavor will be different, but still creamy.

Can I use rotisserie chicken instead?

You can, though you’ll miss that spicy seared crust. Toss shredded rotisserie chicken with Cajun seasoning and heat it before serving.

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Want More Creamy Pasta Ideas?

You might also love the Buffalo Chicken Lasagna Recipe, for a spicy, cheesy layered bake. Or try my Delicious Beef Bowtie Pasta when you want a rich red-meat twist on creamy pasta.

Need a veggie-rich version? The Creamy Broccoli Cheddar Soup makes a great starter. And if you want more meaty comfort, the Garlic Sausage Alfredo Rigatoni brings smoky notes to the table.

The Best Baked Cream Cheese Spaghetti is another pasta winner that’s a reader favorite.

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Pin and Tell Me How Yours Turned Out

You can save this to your pasta night boards for next time. Just hit that Pin button.

And if you make it, I’d love to hear how it turned out. Did you go heavy on the Cajun? Add veggies? Drop your spin in the comments below.

Find more of my daily comfort dishes on Pinterest @LadyPlate.

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