Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

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Craving a weeknight dinner that tastes like it came straight out of a restaurant kitchen? This Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce brings all the bold, smoky flavors of the South with an ultra-smooth, cheesy finish.

This recipe fuses Cajun-spiced chicken with rotini pasta that clings beautifully to a homemade mozzarella alfredo sauce. It’s the perfect storm of creamy meets spicy—comforting and indulgent, yet packed with character. One bite and you’ll want it on repeat.

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Preparation Phase & Tools to Use

To bring this dish to life, you’ll need:

• Large Skillet or Sauté Pan: This is crucial for searing the chicken evenly and building flavor with the spices.
• Medium Saucepan: Use this to create the silky mozzarella Alfredo sauce—a nonstick version makes for easier cleanup.
• Pasta Pot with Strainer: Boiling the rotini until al dente in salted water ensures it holds its shape and flavor.
• Tongs or Spatula: These help handle the chicken without tearing it, maintaining juicy texture.
• Grater: For freshly grated mozzarella, which melts more smoothly than pre-shredded cheese.

Having the right tools isn’t just about ease—they directly impact how your dish turns out. A high-heat skillet gives you that perfect chicken char, and freshly grated cheese transforms the sauce from good to exceptional.

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Ingredients for the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

• Chicken Breast: Lean and protein-packed, it soaks up the Cajun spices and stays juicy with a quick sear.
• Rotini Pasta: The spiral shape holds onto the Alfredo sauce in every curve, ensuring flavor in every bite.
• Mozzarella Cheese: Provides that rich, stretchy creaminess essential for the Alfredo base.
• Heavy Cream: Creates a silky texture and helps carry the Cajun heat.
• Parmesan Cheese: Adds sharpness and depth to the sauce, balancing the mozzarella.
• Cajun Seasoning: The star of the show, delivering smoky, spicy warmth.
• Garlic: Brings aroma and subtle heat that pairs well with the seasoning.
• Butter: Used to sauté and flavor the sauce while adding richness.
• Olive Oil: Helps brown the chicken without burning the spices.
• Salt & Black Pepper: Essential for seasoning the pasta water and adjusting final taste.

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How To Make the Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

Step 1: Season and Sear the Chicken

Generously coat your sliced chicken breast with Cajun seasoning, salt, and pepper. In a hot skillet with olive oil, sear until golden brown and cooked through. Remove and set aside.

Step 2: Boil the Rotini

Cook rotini pasta in salted boiling water until al dente. Drain and reserve a bit of pasta water for later use.

Step 3: Build the Alfredo Base

In a separate saucepan, melt butter and sauté garlic until fragrant. Pour in the heavy cream, bringing it to a simmer.

Step 4: Stir in the Cheeses

Lower the heat and slowly stir in grated mozzarella and Parmesan. Mix until the sauce becomes smooth and creamy.

Step 5: Combine and Serve

Add the rotini and chicken into the sauce. Toss everything to coat. If needed, add a splash of reserved pasta water for consistency. Serve hot and enjoy that creamy-spicy perfection.

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How to Serve and Store Creamy Cajun Chicken Rotini with Mozzarella Alfredo Sauce

When serving, pile the pasta into shallow bowls to showcase the creamy coating and colorful Cajun-speckled chicken. Garnish with fresh parsley or chopped green onions for a pop of freshness and a squeeze of lemon if you like a tangy contrast.

This dish is best enjoyed hot, right after it’s made, when the mozzarella is melty and the sauce is at its creamiest.

For leftovers, store in an airtight container in the fridge for up to 3 days. Reheat gently on the stove or in the microwave with a splash of cream or milk to loosen the sauce. Freezing isn’t recommended as it may alter the texture of the creamy sauce.

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Frequently Asked Questions

Can I use a different type of pasta?

Absolutely. Penne, fettuccine, or bowtie pasta all work well, but rotini holds the sauce especially well.

What if I don’t have Cajun seasoning?

You can mix your own using paprika, garlic powder, onion powder, cayenne, oregano, and thyme. Adjust the spice level to your preference.

Is there a lighter version of this dish?

Yes, you can swap heavy cream with half-and-half or whole milk, and use part-skim mozzarella. The sauce won’t be as rich, but still tasty.

Can I make this dish vegetarian?

Certainly! Skip the chicken and add sautéed mushrooms, zucchini, or bell peppers for a flavorful twist.

What sides go well with this pasta?

A crisp Caesar salad, roasted asparagus, or garlic bread makes excellent pairings.

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Want More Creamy Chicken Pasta Ideas?

If creamy, hearty pasta is your comfort zone, you’re in for a treat.

You might also like the Easy Cajun Chicken Alfredo with Broccoli, a vibrant mix of spicy chicken and fresh greens. For beef lovers, the Delicious Beef Bowtie Pasta brings bold flavors in every forkful.

Looking for something baked and cheesy? The Best Baked Cream Cheese Spaghetti is a crowd-pleaser. Or check out the Buffalo Chicken Lasagna Recipe for a spicy, oven-ready twist on the classic.

And if you love variety in texture, don’t miss the Garlic Sausage Alfredo Rigatoni for that satisfying meaty bite.

Pin and Tell Me How Yours Turned Out

You can save this to your favorite pasta boards for easy access. Just hit the Pin button!

If you make this dish, let me know in the comments—Did you go spicier? Did you use a different cheese? I’m always excited to hear how it turned out.

For more creamy, indulgent recipes and quick weeknight dinners, follow me on Pinterest @LadyPlate.

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