Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

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Craving a creamy pasta dish that packs a punch of flavor? This Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce is the ultimate comfort food—savory, slightly spicy, and irresistibly cheesy. Imagine juicy chicken breasts coated in bold Cajun seasoning, seared until golden, then paired with tender bowtie pasta tossed in a luscious Alfredo sauce enriched with garlic and Parmesan. It’s the kind of dinner that wins over both weeknight cooks and weekend dinner party guests.

What makes this dish even more appealing is how it balances creamy richness with smoky Cajun spice. The bowtie pasta holds the sauce beautifully, while the chicken adds heartiness and texture. It’s a one-plate meal that feels indulgent yet comforting, and the leftovers (if you’re lucky enough to have any) taste even better the next day.

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Preparation Phase & Tools to Use

To make this dish shine, having the right tools makes all the difference:

• Large Skillet or Cast-Iron Pan: Essential for searing the Cajun chicken to get that caramelized crust.
• Large Pot: Needed for boiling the bowtie pasta until perfectly al dente.
• Wooden Spoon or Silicone Spatula: Ideal for stirring the Alfredo sauce without scratching your pan.
• Sharp Knife and Cutting Board: For slicing the chicken evenly so it cooks consistently.
• Measuring Cups & Spoons: Crucial for getting the right balance of Cajun spice, cream, and cheese.

Each of these tools helps streamline the cooking process while ensuring your chicken is juicy, your pasta perfectly cooked, and your Alfredo sauce smooth and flavorful.

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Ingredients for the Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

Every ingredient in this dish brings a unique flavor or texture that makes the pasta truly memorable:

• Chicken Breasts: Lean protein that soaks up the Cajun seasoning and adds hearty bites.
• Cajun Seasoning: The star of the show—bringing smoky, spicy, and herby notes.
• Bowtie Pasta (Farfalle): Holds the Alfredo sauce perfectly in its ridges and folds.
• Butter: Creates a rich base for the garlic and sauce.
• Garlic: Fresh cloves bring sharp, savory flavor that enhances the Alfredo.
• Heavy Cream: Makes the Alfredo sauce luxuriously creamy.
• Parmesan Cheese: Adds nutty, salty depth to balance the spice.
• Mozzarella Cheese: Melts beautifully for that extra cheesy pull.
• Olive Oil: Helps sear the chicken to golden perfection.
• Fresh Parsley: Adds color and freshness at the finish.

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How To Make the Cheesy Garlic Cajun Chicken Bowtie Pasta in Alfredo Sauce

Step 1: Season and Sear the Chicken

Pat dry chicken breasts, coat them generously with Cajun seasoning, then sear in olive oil over medium-high heat until golden on both sides and cooked through. Slice into strips and set aside.

Step 2: Boil the Pasta

Cook the bowtie pasta in salted boiling water until al dente. Drain, reserving about a cup of pasta water.

Step 3: Make the Garlic Alfredo Sauce

In a large skillet, melt butter and sauté minced garlic until fragrant. Pour in heavy cream, stir, and let it simmer gently. Add Parmesan and mozzarella, whisking until smooth and creamy.

Step 4: Combine Pasta and Sauce

Add the cooked pasta to the Alfredo sauce, tossing to coat evenly. If the sauce feels too thick, use reserved pasta water to loosen it.

Step 5: Bring It All Together

Top the creamy pasta with sliced Cajun chicken. Garnish with parsley for a fresh touch and an extra sprinkle of Parmesan if desired.

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Serving and Storing Cheesy Garlic Cajun Chicken Bowtie Pasta

This dish is best enjoyed fresh, straight off the skillet when the Alfredo sauce is silky, and the chicken is juicy. Serve it with a side of garlic bread or a crisp green salad to balance the richness. For drinks, a chilled glass of white wine or sparkling water with lemon pairs beautifully.

Leftovers? Store them in an airtight container in the refrigerator for up to 3 days. Reheat gently in a skillet over low heat with a splash of cream or milk to bring the sauce back to life.

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Frequently Asked Questions

Can I use a different pasta shape?

Yes! Penne, rigatoni, or fettuccine all work well since they hold creamy sauces.

How spicy is Cajun seasoning?

It varies by brand, but generally it has a mild-to-medium heat. You can add cayenne pepper if you want extra spice.

Can I make this ahead of time?

You can cook the chicken and pasta ahead, but for the best flavor, prepare the Alfredo sauce fresh before serving.

What can I substitute for heavy cream?

Half-and-half works in a pinch, though the sauce won’t be as rich. For a lighter option, try evaporated milk.

Is there a vegetarian version?

Yes—skip the chicken and substitute roasted vegetables like mushrooms, zucchini, or bell peppers.

Can I bake this as a casserole?

Absolutely! Layer the pasta, sauce, and chicken in a baking dish, sprinkle with extra cheese, and bake until bubbly.

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Want More Pasta Dinner Ideas?

If you loved this Cheesy Garlic Cajun Chicken Bowtie Pasta, you might also enjoy the Delicious Beef Bowtie Pasta for another hearty bowtie twist. For something smoky and bold, the One Skillet Smoky Cajun BBQ Chicken Pasta is a fantastic pick.

Fans of creamy sauces should try the Creamy Cajun Chicken Pasta, which has a similar spice kick but with a slightly different texture. Or, if you like mixing flavors, the Beef and Bowtie Pasta with Alfredo Sauce offers a savory variation.

And for even more inspiration, check out my Pinterest LadyPlate page where I share daily recipe creations.

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Pin and Tell Me How Yours Turned Out

Save this recipe to your pasta boards so it’s easy to find next time—just click the Pin button.

If you make it, I’d love to hear your twist! Did you add extra cheese? Maybe roasted veggies? Leave a comment below and share your version. I always enjoy seeing how others bring these dishes to life.

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