Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

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Rich, bold, and irresistibly creamy, Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce is the kind of dinner that turns ordinary evenings into something unforgettable. Picture a bed of perfectly cooked spaghetti drenched in a velvety cheese sauce, laced with spicy Cajun flair, and topped with juicy browned beef. This dish wraps comfort and indulgence into every single bite.

The harmony between the heat of the Cajun spice and the smoothness of the three-cheese sauce is where the magic lives. Whether you’re spicing up a weeknight meal or serving guests something special, this pasta delivers on both flavor and satisfaction. It’s hearty, comforting, and just adventurous enough to keep things interesting.

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What Kind of Pasta Should I Use?

Traditional spaghetti works beautifully here, holding the sauce well and offering that satisfying chew. But if you want something a bit different, try linguine or bucatini—they’re great at cradling that luscious cheese sauce. Avoid very fine pastas like angel hair, as they can get overwhelmed by the richness of the dish.

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Ingredients for the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Ground Beef
Adds savory depth and satisfying protein to the dish. Browning it well gives you that essential base flavor.

Spaghetti
A classic base that balances the creamy sauce. Cook it to al dente so it holds up under the sauce.

Cajun Seasoning
The signature kick. It infuses the beef with smoky, peppery heat and brings the dish’s Southern soul to life.

Heavy Cream
Forms the foundation of the sauce, giving it rich body and luxurious texture.

Cream Cheese
Melts into the sauce to add tangy silkiness and balance the heat from the Cajun spice.

Mozzarella Cheese
For that irresistible stretch and mild creaminess.

Parmesan Cheese
Adds sharp, salty depth that anchors the richness of the sauce.

Butter and Garlic
The aromatic base for the sauce. Garlic adds bold flavor, while butter gives smooth richness.

Fresh Parsley (optional)
Brightens and freshens the final dish with a pop of green.

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How To Make the Cajun Beef Spaghetti in Creamy Three-Cheese Parmesan Sauce

Step 1: Cook the Pasta

Bring a large pot of salted water to a boil and cook the spaghetti until al dente. Drain, toss with a little butter or olive oil to prevent sticking, and set aside.

Step 2: Brown the Beef

In a large skillet over medium heat, cook the ground beef until deeply browned and slightly crispy at the edges. Season generously with Cajun seasoning and break the meat into bite-sized crumbles as it cooks. Remove from skillet and set aside.

Step 3: Build the Creamy Base

In the same skillet, melt butter and sauté minced garlic until fragrant. Pour in the heavy cream, stir, and bring it to a gentle simmer. Add the cream cheese and stir until fully melted into the sauce.

Step 4: Add the Cheeses

Lower the heat and slowly whisk in the shredded mozzarella and grated Parmesan cheese. Stir until the sauce is completely smooth and luscious. Season with more Cajun seasoning if desired.

Step 5: Combine and Finish

Add the cooked spaghetti into the skillet and toss well to coat each strand in the cheese sauce. Fold the browned beef back in and gently mix until evenly distributed.

Step 6: Serve

Plate the pasta in generous swirls, topping with extra beef and a sprinkle of fresh parsley. A final dusting of black pepper or more Parmesan is always welcome.

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Serving and Storing This Cajun Beef Spaghetti

Serve this pasta piping hot, right after the cheese sauce is fully blended and smooth. It makes an excellent main dish for a cozy family dinner or a gathering where bold flavor is welcomed. Pair it with a crisp green salad or roasted vegetables to round out the richness.

To store, let the spaghetti cool completely before transferring to an airtight container. It will keep in the refrigerator for up to 4 days. Reheat gently on the stove or in the microwave with a splash of cream or milk to loosen the sauce.

Frequently Asked Questions

Can I use a different type of meat?

Absolutely. Ground turkey or Italian sausage are great substitutes and will bring their own unique flair.

What cheeses can I swap in?

Fontina, provolone, or gouda can be used in place of mozzarella for a deeper flavor. For Parmesan, pecorino is a solid swap.

Is this dish very spicy?

It has a medium heat level from the Cajun seasoning, but you can always reduce the amount to your taste.

Can I make this dish ahead of time?

Yes, but the texture is best right after cooking. If making ahead, prepare the sauce and beef separately and combine with pasta when reheating.

What pasta alternatives work well here?

Linguine, fettuccine, or even penne hold up well to the thick sauce and meaty topping.

Is it freezer-friendly?

Yes, though the cheese sauce may separate slightly when thawed. Stirring in a bit of cream during reheating can help restore its smoothness.

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Want More Dinner Pasta Ideas?

You might also like the Delicious Beef Bowtie Pasta, where tender pasta and savory beef come together in a creamy embrace. Or try One Skillet Smoky Garlic Butter Parmesan Steak Pasta for a bold, flavor-packed option with easy cleanup.

For a rich and cheesy twist, the Best Baked Cream Cheese Spaghetti offers oven-baked comfort. Looking for a little spice? The One Skillet Smoky Cajun BBQ Chicken Pasta balances heat with smoky depth.

Prefer a saucier blend? Check out the Beef and Rotini in Garlic Parmesan Sauce—a creamy, garlicky pasta dream.

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If you make it, I’d love to hear how it turned out. Did you change up the cheese blend? Did you go heavier on the Cajun heat? Leave a comment below. I’m always curious how others bring their twist to the dish.

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