Bubble Up Biscuit Pizza Casserole

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Craving the comforting flavors of pizza but want to skip the dough kneading and rolling? Bubble Up Biscuit Pizza Casserole brings all that cheesy, saucy, pepperoni-loaded joy in a fluffy, pillowy bake that comes together with a few clever shortcuts. It’s the ultimate mashup of two comfort food classics: pizza and casserole.

This dish is a weeknight winner. Thanks to store-bought biscuit dough, it bakes up fast and fluffy, absorbing that savory pizza sauce and melting into layers of mozzarella and pepperoni. Each bite delivers soft biscuit pockets surrounded by bubbly cheese and crisp edges—a guaranteed crowd-pleaser that even picky eaters won’t resist.

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Preparation Phase & Tools to Use

Before diving into this delicious casserole, gather your kitchen basics. You’ll need:

• Oven — Preheat to 350°F (175°C). A reliable oven ensures even baking so the biscuits puff up golden without burning.
• 9×13-inch Baking Dish — This size gives the biscuits room to rise and spread out while creating an evenly layered casserole.
• Mixing Bowl — A large one to toss the biscuit pieces with sauce and cheese, ensuring even coverage.
• Kitchen Shears or Knife — For cutting the biscuits into smaller, bite-sized pieces.
• Spatula or Wooden Spoon — To mix everything gently and to help with layering.
• Aluminum Foil (optional) — If the casserole browns too quickly, covering it midway helps prevent burnt cheese while the center finishes cooking.

Having these tools ready helps streamline your process, keeps cleanup minimal, and ensures a bubbly casserole with the perfect golden top.

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Ingredients for the Bubble Up Biscuit Pizza Casserole

• Refrigerated Biscuit Dough — This is the base that gives the dish its signature “bubble-up” texture. When baked, the dough rises and separates into soft, fluffy bites throughout the casserole.
• Pizza Sauce — Rich and tangy, the sauce coats the biscuit pieces and infuses every layer with bold tomato flavor.
• Shredded Mozzarella Cheese — Essential for that classic pizza pull and gooey texture. It binds the biscuits together in cheesy goodness.
• Pepperoni Slices — Adds a salty, savory depth with crispy edges once baked. A must-have topping for pizza lovers.
• Italian Seasoning — Adds herbaceous aroma and balances the acidity of the sauce. Just a sprinkle goes a long way.
• Fresh Parsley (optional) — Chopped parsley adds a touch of freshness and visual appeal to the finished dish.

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How To Make the Bubble Up Biscuit Pizza Casserole

Step 1: Preheat & Prep

Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish to prevent sticking and ensure easy serving.

Step 2: Cut the Biscuits

Using a sharp knife or kitchen shears, cut each biscuit into four equal pieces. This allows them to cook through evenly and soak up more sauce and cheese.

Step 3: Mix the Ingredients

In a large mixing bowl, combine the biscuit pieces, pizza sauce, and half of the shredded mozzarella. Stir gently until all the biscuit chunks are coated and cheese is distributed.

Step 4: Assemble the Casserole

Pour the mixture into the greased baking dish. Spread it out evenly. Top with the remaining mozzarella and arrange the pepperoni slices across the top. Sprinkle with Italian seasoning.

Step 5: Bake to Perfection

Bake uncovered for 25–30 minutes, or until the biscuits are puffed up and golden, and the cheese is bubbling. If the top starts browning too quickly, cover with foil halfway through.

Step 6: Cool & Garnish

Let it rest for 5 minutes before serving. Garnish with chopped fresh parsley for an added pop of color and flavor.

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How to Serve and Store Bubble Up Biscuit Pizza Casserole

This casserole is best served fresh from the oven while the cheese is melty and the biscuits are fluffy and crisp on the edges. Slice into generous squares and serve with a light side salad or steamed veggies to balance out the richness.

For storing, let the casserole cool completely. Transfer leftovers into an airtight container and refrigerate for up to 4 days. To reheat, pop individual portions in the microwave for 1-2 minutes or bake in the oven at 300°F until warmed through. It also freezes well—wrap tightly and freeze for up to 2 months. Thaw overnight before reheating.

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Frequently Asked Questions

How do I know the biscuits are cooked through?

Look for golden brown tops and puffed-up layers. If you’re unsure, insert a toothpick into the center. If it comes out clean, the biscuits are done.

Can I use homemade biscuit dough?

Yes, though the convenience of refrigerated dough is what makes this dish so quick. Homemade dough can add a richer, more buttery flavor.

What other toppings can I add?

You can customize like a pizza! Try crumbled sausage, mushrooms, bell peppers, olives, or jalapeños.

Can I make this casserole ahead of time?

You can assemble it a few hours in advance and refrigerate until ready to bake. Let it sit at room temp for 15 minutes before baking.

Is this kid-friendly?

Absolutely! The cheesy, saucy layers and soft biscuit bites are a hit with children, and it’s easy to adjust toppings to suit picky eaters.

Can I make it vegetarian?

Of course! Just skip the pepperoni and use your favorite veggie toppings like spinach, tomatoes, or roasted red peppers.

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Want More Pizza Casserole Ideas?

You might also like the Pepperoni Pizza Casserole if you want a more traditional layered approach with pasta. For veggie-packed options, the Cheesy Broccoli Rice Casserole brings the same cozy vibe with a nutritious twist.

If you’re after bold flavors, try the Buffalo Chicken Lasagna Recipe — it’s spicy, creamy, and ultra comforting. Or go hearty with the Delicious Beef Bowtie Pasta for a meaty casserole that’s weeknight-ready.

Another creative spin? The Sloppy Joe Casserole turns your favorite sandwich into a bubbly baked dinner.

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If you make it, I’d love to hear your twist! Did you try different toppings? Maybe extra cheese? Let me know in the comments — and check out my daily recipe shares on Pinterest @LadyPlate.

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